张路教授课题组
纳米生物医学实验室

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成果总览
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临床转化应用

代表作

Lu Zhang#, Di Jing#, Nian Jiang, Tatu Rojalin, Christopher M. Baehr, Dalin Zhang, Wenwu Xiao, Yi Wu, Zhaoqing Cong, Jian Jian Li, Yuanpei Li, Lei Wang*, Kit S. Lam*. Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo. Nature Nanotechnology 2020, 15 (2), 145-153. (IF: 40.523) https://www.nature.com/articles/s41565-019-0626-4

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文章

2024

1. Chunping Mao, Fuan Deng, Wanning Zhu, Leiming Xie, Yijun Wang, Guoyin Li, Xingke Huang, Jiahui Wang, Yue Song, Ping Zeng, Zhenpeng He, Jingnan Guo, Yao Suo, Yujing Liu, Zhuo Chen, Mingxi Yao, Lu Zhang*, Jun Shen*. In Situ Editing of Tumour Cell Membranes Induces Aggregation and Capture of PD-L1 Membrane Proteins for Enhanced Cancer Immunotherapy. Nature Communications 2024, 15, 9723. (IF: 14.7) https://doi.org/10.1038/s41467-024-54081-9

2. Yichi Chen, Yijun Wang, Ruotian Zhang, Fengyi Wang, Xin Lin, Tong Wang, Wenyuan Zhang, Fuan Deng, Bolin Wu, Haitao Shang, Wen Cheng*, Lu Zhang*. In Situ Transformable Fibrillar Clusters Disrupt Intracellular Copper Metabolic Homeostasis by Comprehensive Blockage of Cuprous Ions Efflux. Small 2024, 2406802. (IF: 13.0) https://doi.org/10.1002/smll.202406802‍

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3. Wenyuan Zhang, Liejing Lu, Zheng Zhu, Fuan Deng, Wenchang Zhang, Fengyi Wang, Ping Zeng, Haonan Shi, Tong Wang, Yichi Chen, Yue Song, Yiping Liu, Tianze Kang, Kai Li, Jie Mao, Zhengwei Liu*, Lu Zhang*. A Manganese-Based Nanodriver Coordinates Tumor Prevention and Suppression through STING Activation in Glioblastoma. Advanced Healthcare Materials 2024, 202400421. (IF: 10.0) https://onlinelibrary.wiley.com/doi/10.1002/adhm.202400421‍


2023

4. Wenyuan Zhang, Jianrui Zhang, Yijun Wang, Senyao Wang, Yitian Wu, Wenchang Zhang, Minghui Wu, Li Wang, Guoheng Xu, Fuan Deng, Wenchao Liu, Zhengwei Liu*, Lu Chen*, Kai Xiao*, Lu Zhang*. In Vitro Detection of S100B and Severity Evaluation of Traumatic Brain Injury Based on Biomimetic Peptide-Modified Nanochannels. Small 2023, 2306809. (IF: 13.0) https://onlinelibrary.wiley.com/doi/10.1002/smll.202306809‍

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2022

5. Di Jing, Nian Jiang, Fengyi Wang, Chunping Mao, Shujun Han, Pui Yan Ho, Wenwu Xiao, Yuanpei Li, Jian-Jian Li, Lu Zhang* (co-corresponding), Kit S Lam*. Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect. Biomaterials 2022, 289, 121769. (IF: 15.304) https://www.sciencedirect.com/science/article/pii/S0142961222004094‍

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6. Lu Zhang*, Ruonan Bo, Yi Wu, Longmeng Li, Zheng Zhu, Ai-Hong Ma, Wenwu Xiao, Yanyu Huang, Tatu Rojalin, Xingbin Yin, Chunping Mao, Fengyi Wang, Yongheng Wang, Hongyong Zhang, Kelmen E. Low, Kiana Lee, Yousif Ajena, Di Jing, Dalin Zhang, Christopher M. Baehr, Ruiwu Liu, Lei Wang*, Yuanpei Li*, Kit S. Lam*. Programmable Bispecific Nano-immunoengager That Captures T Cells and Reprograms Tumor Microenvironment. Nano Letters, 2022, 22 (17): 6866–6876. (Supplementary Cover, IF: 12.262) https://pubs.acs.org/doi/10.1021/acs.nanolett.2c00582‍‍   

                       Supplementary Cover （内页封面）

7. Zhiqin Zhang, Kaixin Wang, Manting Liu, Panxiang Hu, Yuchen Xu, Dongge Yin, Yuchang Yang, Xiaoxv Dong, Changhai Qu, Lu Zhang* (co-corresponding), Jian Ni*, Xingbin Yin*. Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer. Drug Delivery, 2022, 29 (1):1608-1619. (IF: 6.819) https://pubmed.ncbi.nlm.nih.gov/35612320/

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2021

8. Lu Zhang, Yi Wu, Xingbin Yin, Zheng Zhu, Tatu Rojalin, Wenwu Xiao, Dalin Zhang, Yanyu Huang, Longmeng Li, Christopher M. Baehr, Xingjian Yu, Yousif Ajena, Yuanpei Li, Lei Wang*, Kit S. Lam*. Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Pharmacokinetics of Smart Nanomaterials. ACS Nano 2021, 15 (1), 468-479. (IF: 18.027) https://pubs.acs.org/doi/10.1021/acsnano.0c05065?fig=tgr1&ref=pdf‍

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9. Pei-Pei Yang#, Yi-Jing Li#, Yan Cao#, Lu Zhang, Jia-Qi Wang, Zi-Wei Lai, Kuo Zhang, Diedra Shorty, Wenwu Xiao, Hui Cao, Lei Wang*, Hao Wang*, Ruiwu Liu*, Kit S. Lam*. Rapid discovery of self-assembling peptides with one-bead one-compound peptide library. Nature Communications 2021, 12, 4494. (IF: 17.694) https://www.nature.com/articles/s41467-021-24597-5

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10. Christopher M. Baehr, Lu Zhang, Yi Wu, Andras Domokos, Wenwu Xiao, Lei Wang, Kit S.Lam*. Transformable amyloid-beta mimetic peptide amphiphiles for lysosomal disruption in non-small cell lung cancer. Biomaterials 2021, 277, 121078. (IF: 15.304) https://www.sciencedirect.com/science/article/pii/S0142961221004348‍


2020

11. Lu Zhang#, Di Jing#, Nian Jiang, Tatu Rojalin, Christopher M. Baehr, Dalin Zhang, Wenwu Xiao, Yi Wu, Zhaoqing Cong, Jian Jian Li, Yuanpei Li, Lei Wang*, Kit S. Lam*. Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo. Nature Nanotechnology 2020, 15 (2), 145-153. (IF: 40.523) https://www.nature.com/articles/s41565-019-0626-4

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12. Hao Wu#, Lu Zhang#(co-first), Jinfan Yang, Ruonan Bo, Hongxu Du, Kai Lin, Dalin Zhang, Mythili Ramachandran, Yingbin Shen, Yangxi Xu, Xiangdong Xue, Zhao Ma, Aaron Raymond Lindstrom, Randy Carney, Tzu-Yin Lin, Yuanpei Li. Rotatable Aggregation-Induced-Emission/Aggregation Caused-Quenching Ratio Strategy for Real-Time Tracking Nanoparticle Dynamics. Advanced Functional Materials 2020, 30 (15), 1910348. (IF: 19.924) https://onlinelibrary.wiley.com/doi/10.1002/adfm.201910348‍

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13. Zhaoqing Cong, Lu Zhang, Si-Qi Ma, Kit S.Lam, Fei-Fei Yang*, YongHong Liao*. Size-Transformable Hyaluronan Stacked Self-Assembling Peptide Nanoparticles for Improved Transcellular Tumor Penetration and Photo-Chemo Combination Therapy. ACS Nano 2020, 14 (2), 1958-1970. (IF: 18.027) https://pubs.acs.org/doi/10.1021/acsnano.9b08434‍

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14. Lu Zhang#, Hao Wu#, Yuanpei Li*, Kit S. Lam*. Reversible Cross-Linked Polymeric Micelles for Drug Delivery. Elsevier, 2020. (Academic Treatise) https://www.sciencedirect.com/science/article/pii/B9780081029855000115


15. Mengru Cai, Liuying Qin, Longtai You, Yu Yao, Huimin Wu, Zhiqin Zhang, Lu Zhang* (co-corresponding), Xingbin Yin*, Jian Ni*. Functionalization of MOF-5 with Mono-Substituents: Effects on Drug Delivery Behavior. RSC Advances 2020, 10 (60), 36862-36872. (IF: 4.036) https://pubs.rsc.org/en/content/articlelanding/2020/ra/d0ra06106a


16. Christopher M. Baehr，Lu Zhang, Kit S. Lam*. Abstract 1740: Transformable amyloid-beta mimetic peptide amphiphiles for lysosomal disruption and cisplatin sensitization in non-small cell lung cancer. Cancer Research, 2020. (IF: 11.2) https://aacrjournals.org/cancerres/article/80/16_Supplement/1740/641705/Abstract-1740-Transformable-amyloid-beta-mimetic


2019

17. Lu Zhang, Yanyu Huang, Aaron Raymond Lindstrom, Tzu-Yin Lin, Kit S Lam, Yuanpei Li*. Peptide-based materials for cancer immunotherapy. Theranostics 2019, 9 (25), 7807-7825. (IF: 11.6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831480/‍

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2018

18. Lu Zhang#, Tinghui Yin#, Bo Li, Rongqin Zheng*, Chen Qiu, Kit S. Lam*, Qi Zhang, Xintao Shuai*. Size-Modulable Nanoprobe for High-Performance Ultrasound Imaging and Drug Delivery against Cancer. ACS Nano 2018, 12 (4), 3449-3460. (IF: 18.027) https://pubs.acs.org/doi/10.1021/acsnano.8b00076‍

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19. Lu Zhang#, Di Jing#, Lei Wang, Yuan Sun, Jian Jian Li, Brianna Hill, Fan Yang, Yuanpei Li*, Kit S. Lam*. Unique Photochemo-Immuno-Nanoplatform against Orthotopic Xenograft Oral Cancer and Metastatic Syngeneic Breast Cancer. Nano Letters 2018, 18 (11), 7092-7103. (IF: 12.262) https://pubs.acs.org/doi/10.1021/acs.nanolett.8b03096‍

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20. Hao Wu#, Lu Zhang#(co-first), Yuanpei Li*; Kit S. Lam*; Stimuli-Responsive Materials in Theranostics. Royal Society of Chemistry, 2018. (Academic Treatise) https://pubs.rsc.org/en/content/chapter/bk9781788011136-00284/978-1-78801-113-6


21. Hong Xiao, Jin He, Xiaoxia Li, Bo Li, Lu Zhang, Yong Wang*, Du Cheng, Xintao Shuai*. Polymeric Nanovesicles as Simultaneous Delivery Platforms with Doxorubicin Conjugation and Elacridar Encapsulation for Enhanced Treatment of Multidrug-Resistant Breast Cancer. Journal of Materials Chemistry B 2018, 6 (45), 7521-7529. (IF: 7.571) https://pubs.rsc.org/en/content/articlelanding/2018/TB/C8TB01829D


22. Yi Huang, Xiaoxia Li, Lu Zhang, Xiaoyan Chen, Chengbo Liu, Jingqin Chen, Yong Wanga*, XinTao Shuai. Multifunctional Nanoplatform Based on pH-responsive Micelle Coated with Discontinuous Gold Shell for Cancer Photothermo-chemotherapy and Photoacoustic Tomography. Chinese Journal of Polymer Science, 2018, 36, 1139-1149. (IF: 3.815) https://link.springer.com/article/10.1007/s10118-018-2141-8


2016

23. Yu Guo#, Jing Wang#, Lu Zhang#(co-first), Shunli Shen#, Ruomi Guo, Yang Yang*, Wenjie Chen, Yiru Wang, Guihua Chen*, Xintao Shuai*. Theranostical Nanosystem-Mediated Identification of An Oncogene and Highly Effective Therapy in Hepatocellular Carcinoma. Hepatology 2016, 63 (4), 1240-1255. (IF: 17.298) https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.28409‍

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24. Lu Zhang#, Hong Xiao#, Jingguo Li, Du Cheng*, Xintao Shuai*. Co-delivery of doxorubicin and arsenite with reduction and pH dual-sensitive vesicle for synergistic cancer therapy. Nanoscale 2016, 8 (25), 12608-12617. (IF: 8.307) https://pubs.rsc.org/en/content/articlelanding/2016/NR/C5NR07868G

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25. Jingguo Li, Lu Zhang, Yujie Lin, Hong Xiao, Mingxiang Zuo, Du Cheng, Xintao Shuai*. A pH-Sensitive Prodrug Micelle Self-Assembled from MultiDoxorubicin-Tailed Polyethylene Glycol for Cancer Therapy. RSC Advances. 2016, 6 (11), 9160-9163. (IF: 4.036) https://pubs.rsc.org/en/content/articlelanding/2016/ra/c5ra2729


2014

26. Faming Gong, Zuoquan Zhang, Xiaodong Chen, Lu Zhang, Xingsu Yu, Qihua Yang, Xintao Shuai, Biling Liang*, Du Cheng*. A dual ligand targeted nanoprobe with high MRI sensitivity for diagnosis of breast cancer[J]. Chinese Journal of Polymer Science, 2014, 32 (3), 321-332. (IF: 3.815) https://link.springer.com/article/10.1007/s10118-014-1399-8


主持科研基金项目  1) 广东省基础与应用基础研究基金自然科学基金面上项目（2024）

 2) 国家重点研发计划“合成生物学”重点专项（2023)

 3) 国家自然科学基金优秀青年科学基金项目（海外2022）

 4) 国家自然科学基金面上项目（2022）  5) 深圳市自然科学基金面上项目（2022）


曾主持或参与项目

 1) National Cancer Institute (NCI), 1R01CA247685-01, HER2 targeting transformable nanotherapeutic platform against HER2+ cancers,

     2020.02-2025.01, $572,096 (Each year).

 2) Department of Defense (DOD), W81XWH-19-1-0204, Delivery of targeting nano-photo-imiquimod to greatly enhance check point

     blockade immunotherapy of patients with advanced bladder cancer, 2019.07-2023.06, $1,037,215 (Each year).

 3) Department of Defense (DOD), W81XWH-19-1-0159, Novel nano-photo-immunotherapy against ovarian cancer, 2019.06-2022.06,

     $234,000 (Each year).

 4) National Cancer Institute (NCI), 5R01CA115483-13, Therapeutic targeting agents for ovarian cancer, 2015.01-2021.04, $334,535  (Each year).

 5) National Institute of Biomedical Imaging and Bioengineering (NIBIB), 2R01EB012569-09, Targeting nanotherapeutics against murine and          feline oral cancer, 2010.12-2021.05, $518,074 (Each year).

国际专利

1) Kit S. Lam; Lu Zhang; Smart peptides and transformable nanoparticles for cancer immunotherapy, 2021-2-18, WIPO, PCT/US2020/046495

2) Kit S. Lam; Lu Zhang; Cyanine-based telodendrimers and uses for treating cancer, 2020-5-3, WIPO, PCT/US2019/049080


国内专利

1）罗智；李金娜·哈比布利纳；张宇航；张路；姚明曦；李喆；一种液态金属墨水及其制备方法和应用，2024-07-17，2024109674906

2）鲁敬雄；张路；曹玲燕；杜咏轩；一种DNA水凝胶及其制备方法，2024-08-23，2024111689897

3）鲁敬雄；张路；曹玲燕；杜咏轩；一种用于核酸检测的 DNA 水凝胶传感器及其制备方法，2024-08-23，202411169049X

4）张路；沈君；毛椿平；一种用于结合PD-L1的多肽纳米材料及其制备方法与应用，2023-10-13，CN202310758599.4

5）帅心涛；张路；邱晨；黄毅；左明祥；程度；一种pH与温度双重敏感性的纳米囊泡及其制备方法和应用，2016-07-12，CN201610548026.9


临床转化应用

   已开发多种 GMP 及 GLP 级别的树枝状大分子聚合物包载化疗药和免疫药物的纳米药剂, 化疗药 (Doxorubicin, Paclitaxel 等)，免疫药物(Resiquimod, Imiquimod等)；并在美国获准应用于鼠、兔、猫和狗等动物的膀胱癌、口腔癌、卵巢癌和乳腺癌等模型的临床前研究。