张路教授课题组
纳米生物医学实验室

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4) Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Ph

发表时间：2020-12-17 12:42

题目：Tumor Receptor-Mediated In Vivo Modulation of the Morphology, Phototherapeutic Properties, and Pharmacokinetics of Smart Nanomaterials

摘要：To be clinically efficacious, nanotherapeutic drugs need to reach disease tissues reliably and cause limited side effects to normal organs and tissues. Here, we report a proof-of-concept study on the development of a smart peptidic nanophototherapeutic agent in line with clinical requirements, which can transform its morphology from nanoparticles to nanofibrils at the tumor sites. This in vivo receptor-mediated transformation process resulted in the formation and prolonged tumor-retention of highly ordered (J-aggregate type of photosensitizer) photosensitive peptide nanofibrillar network with greatly enhanced photothermal and photodynamic properties. This strategy of “multiple daily low-intensity laser radiation after each intravenous injection of significantly low-dose of nanomaterials” demonstrated effective elimination of 4T1 orthotopic syngeneic breast cancer in mice. The technology for nanomaterial modulation based on living cell surface receptors, in this case tumor-associated α₃β₁ integrin, has great potential for clinical translation and is expected to improve the therapeutic efficacy against many cancers.‍

全文链接：https://pubs.acs.org/doi/10.1021/acsnano.0c05065?fig=tgr1&ref=pdf

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